After the events in Paris in Taken, relatives of the men whom Bryan Mills (Neeson) killed while searching for his daughter, Kim (Grace), return to their hometown, Tropojë, Albania, for the dead men's funeral. During the ceremony, Murad (Šerbedžija), the employer of the men and father of Marko, a victim whom Bryan killed by electrocution, states that they will find Bryan to avenge the deaths of their loved ones. When arriving at Kim's home to take her on a driving lesson, Bryan learns from her mother Lenore (Janssen), who is currently having relationship problems with her husband, that Kim is not there and that she has a new boyfriend. After Lenore's husband cancels their holiday to China, Bryan suggests that Kim and Lenore join him in Istanbul after he has finished a work assignment there.
After being led to believe that they have not taken him up on the offer, Bryan is surprised to find that Kim and Lenore have indeed flown out to join him. Later, after lunching in the marketplace, Kim stays behind at the hotel in an attempt to help her parents rekindle their relationship. While Bryan and Lenore are out, they are pursued by Murad's men, and, despite Bryan's efforts, Lenore is captured, forcing Bryan to surrender. Before he does so, he calls Kim to explain the situation and tells her to hide. With advice from Bryan, she is able to evade the kidnappers. Bryan wakes up with his hands tied to a pole in a dark room. Using a communications device that he has hidden in his sock, Bryan calls Kim, instructing her to go to the US Embassy and tell them what happened, but she begs for a chance to help him and Lenore, which he decides to give her. Under Bryan's guidance, she opens up his weaponry suitcase and throws a live grenade out of the window. Bryan uses the time it takes for the sound of the explosion to to reach him in order to deduce his location. He then has her take a gun and two more grenades and travel towards his location via the rooftops, while he frees himself from his restraints. Bryan then sends steam up a chimney to pinpoint his location, and Kim drops the gun down the chimney, allowing Bryan to use it to kill the guards and escape the building, leaving Lenore behind while he rescues Kim, who is being chased.